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Synthesis and Investigation of Physicochemical and Biological Properties of Films Containing Encapsulated Propolis in Hyaluronic Matrix

Gohar Khachatryan, Karen Khachatryan, Magdalena Krystyjan, Lidia Krzemińska-Fiedorowicz, Anna Lenart-Boroń, Anna Białecka, Magdalena Krupka, Marcel Krzan, Karolina Blaszyńska, Monika Hanula and Lesław Juszczak

Synthesis and Investigation of Physicochemical and Biological Properties of Films Containing Encapsulated Propolis in Hyaluronic Matrix

ABSTRACT:

The dynamic development of nanotechnology has enabled the development of innovative and novel techniques for the production and use of nanomaterials. One of them is the use of nanocapsules based on biodegradable biopolymer composites. Closing compounds with antimicrobial activity inside the nanocapsule cause the gradual release of biologically active substances into the environment, and the effect on pathogens is regular, prolonged and targeted. Known and used in medicine for years, propolis, thanks to the synergistic effect of active ingredients, has antimicrobial, anti-inflammatory and antiseptic properties. Biodegradable and flexible biofilms were obtained, the morphology of the composite was determined using scanning electron microscopy (SEM) and particle size was measured by the dynamic light scattering (DLS) method. Antimicrobial properties of biofoils were examined on commensal skin bacteria and pathogenic Candida isolates based on the growth inhibition zones. The research confirmed the presence of spherical nanocapsules with sizes in the nano/micrometric scale. The properties of the composites were characterized by infrared (IR) and ultraviolet (UV) spectroscopy. It has been proven that hyaluronic acid is a suitable matrix for the preparation of nanocapsules, as no significant interactions between hyaluronan and the tested compounds have been demonstrated. Color analysis and thermal properties, as well as the thickness and mechanical properties of the obtained films, were determined. Antimicrobial properties of the obtained nanocomposites were strong in relation to all analyzed bacterial and yeast strains isolated from various regions of the human body. These results suggest high potential applicability of the tested biofilms as effective materials for dressings to be applied on infected wounds.

Keywords: nanocapsules; antimicrobial properties; Candida spp.; Staphylococcus spp.; hyaluronic acid; propolis; nanocomposites

Films Containing Encapsulated Propolis in Hyaluronic Matrix  - K. Khachatryan
 Polymers 2023, 15(5), 1271;  https://doi.org/10.3390/polym15051271

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MDPI and ACS Style
Khachatryan, G.; Khachatryan, K.; Krystyjan, M.; Krzemińska-Fiedorowicz, L.; Lenart-Boroń, A.; Białecka, A.; Krupka, M.; Krzan, M.; Blaszyńska, K.; Hanula, M.; et al. Synthesis and Investigation of Physicochemical and Biological Properties of Films Containing Encapsulated Propolis in Hyaluronic Matrix. Polymers 2023, 15, 1271. https://doi.org/10.3390/polym15051271

AMA Style
Khachatryan G, Khachatryan K, Krystyjan M, Krzemińska-Fiedorowicz L, Lenart-Boroń A, Białecka A, Krupka M, Krzan M, Blaszyńska K, Hanula M, et al. Synthesis and Investigation of Physicochemical and Biological Properties of Films Containing Encapsulated Propolis in Hyaluronic Matrix. Polymers. 2023; 15(5):1271. https://doi.org/10.3390/polym15051271

Chicago/Turabian Style
Khachatryan, Gohar, Karen Khachatryan, Magdalena Krystyjan, Lidia Krzemińska-Fiedorowicz, Anna Lenart-Boroń, Anna Białecka, Magdalena Krupka, Marcel Krzan, Karolina Blaszyńska, Monika Hanula, and et al. 2023. "Synthesis and Investigation of Physicochemical and Biological Properties of Films Containing Encapsulated Propolis in Hyaluronic Matrix" Polymers 15, no. 5: 1271. https://doi.org/10.3390/polym15051271

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